/info/1014/1047.htm

周立全，教授，博士/硕士生导师，华中卓越学者，raybet官网学术前沿青年团队负责人，湖北省人才计划获得者，科技部重点研发计划课题负责人。中国医学科学院北京协和医学院获得博士学位，之后于美国国立卫生研究院（NIH）进行博士后研究。目前就职于雷竞技raybet官方平台。第一/通讯作者文章分别发表在Adv Sci, Nucleic Acids Res, Dev Cell, Cell Rep, Trends Cell Biol等。课题组利用基因编辑小鼠模型、小鼠胚胎干细胞模型、临床生殖标本等，结合显微注射和高通量组学方法，主要研究衰老、环境和遗传等因素通过改变染色质结构从而影响哺乳动物卵母细胞和早期胚胎发育潜能的机制，以揭示哺乳动物生殖发育过程中的转录调控模式和细胞命运决定机理。

地址：雷竞技raybet官方平台

联系电话：027-83692651

电子邮件：zhouliquan@hust.edu.cn

Li-quan Zhou, Professor of Institute of Reproductive Health (IRH), Tongji Medical College (TJMC), Huazhong University of Science and Technology (HUST). He obtained PhD degree in the Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), supervised by Prof. De-pei Liu. He then performed postdoctoral research in National Institutes of Health (NIH), supervised by Prof. Jurrien Dean, NIH Distinguished Investigator. He established his independent lab in 2017. Research interest of Prof. Zhou's group is epigenetic regulation of mammalian oocyte and early embryo, whose chromatin features and cell fate can be impacted by aging, environmental factors and genetic disorders.

Address: 13 Hangkong Road, Wuhan, 430030 P.R. China

Tel: +86-27-83692651

Email: zhouliquan@hust.edu.cn

SELECTED PUBLICATION (Full publication list,

 http://orcid.org/0000-0002-9332-9408

1. Adv Sci. 2025 Mar 16:e2414985. Mitofusin 1 Drives Preimplantation Development by Enhancing Chromatin Incorporation of Histone H3.3. Xiao-Yan Shi^#, Yu Tian, Yu-Fan Wang, Yi-Ran Zhang, Ying Yin, Qing Tian, Lei Li, Bing-Xin Ma*, Ximiao He*, Li-Quan Zhou*

2. Cell Rep. 2025 Jan 28;44(1):115215. Deciphering transcription activity of mammalian early embryos unveils on/off of zygotic genome activation by protein translation/degradation. Yi-Ran Zhang^#, Shi-Meng Guo^#, Xiao-Yan Shi^#, Yi-Wen Ding, Huai-Biao Li, Lei Li, Jia-Wei Xu, Ximiao He, Bing-Xin Ma*, Ying Yin*, Li-Quan Zhou*

3. Adv Sci. 2024 May;11(20):e2308018. Chromatin Modifier EP400 Regulates Oocyte Quality and Zygotic Genome Activation in Mice. Qing Tian^#, Ying Yin^#, Yu Tian^#, Yufan Wang, Yong-Feng Wang, Rikiro Fukunaga, Toshihiro Fujii, Ai-Hua Liao, Lei Li, Wei Zhang, Ximiao He*, Wenpei Xiang*, Li-Quan Zhou*

4. Adv Sci. 2023 Apr;10(12):e2204794. H3K4 Methylation Promotes Expression of Mitochondrial Dynamics Regulators to Ensure Oocyte Quality in Mice. Ning-Hua Mei^#, Shi-Meng Guo^#, Qi Zhou^#, Yi-Ran Zhang, Xiao-Zhao Liu, Ying Yin, Ximiao He, Jing Yang*, Tai-Lang Yin*, Li-Quan Zhou*

5. Nucleic Acids Res. 2022 Jul 8;50(12):6786-6800. H3K36me2 methyltransferase NSD2 orchestrates epigenetic reprogramming during spermatogenesis. Zhiming Li^#,*, Xinzong Zhang, Shiming Xie, Xingping Liu, Caifeng Fei, Xunbin Huang, Yunge Tang*, Li-Quan Zhou*

6. Dev Cell. 2017 Mar 13;40(5):453-466.e5. BTBD18 Regulates a Subset of piRNA-Generating Loci through Transcription Elongation in Mice. Liquan Zhou*, Bertram Canagarajah, Yangu Zhao, Boris Baibakov, Keizo Tokuhiro, Dragan Maric, Jurrien Dean*

7. Trends Cell Biol. 2015 Feb;25(2):82-91. Reprogramming the genome to totipotency in mouse embryos. Li-quan Zhou, Jurrien Dean*

8. Blood. 2014 Jan 9;123(2):261-70. PML4 facilitates erythroid differentiation by enhancing the transcriptional activity of GATA-1. Jie Wu^#, Li-Quan Zhou^#, Wei Yu^#, Zhi-Guo Zhao, Xue-Min Xie, Wen-Tian Wang, Jian Xiong, Man Li, Zheng Xue, Xing Wang, Peng Zhang, Bei-Bei Mao, De-Long Hao, Xiang Lv*, De-Pei Liu*

欢迎对哺乳动物生殖生物学和表观遗传学感兴趣的同学报考硕士和博士，并诚邀相关背景的博士后加盟本团队！